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Using genetic engineering tools in heart muscle and connective tissue cells, the team mutated human tuberin protein in the specific places that were altered by protein kinase G. Two Brazilian geneticists crossbred mild-tempered European honeybees with aggressive African honeybees in hopes of creating a new bee that would fare better in the warm South American climate. The alterations made the cells behave in one of two ways: one type of mutation "turned up" the effect of tuberin all the time while the other essentially "turned down" its effect all the time. But, when the researchers treated the cells with hormones that encourage them to grow, mTORC1 was super-activated and the cells enlarged more than the cells with normal tuberin The robin that lands on Mary's finger in the "Spoonful of S...